Everything you need to know about hypertension
High blood pressure should be treated earlier with lifestyle changes and in some patients with medication. Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure is; calcium channel blocker (amlodipine), blocks the contractile effect of calcium on vascular (arterial) smooth muscle cells with minimal effect on cardiac muscle, and angiotensin II receptor antagonist blocks vasoconstriction and sodium retention on cardiac, vascular smooth muscle, adrenal and renal cells(losartan). These combined substances have an additive synergetic antihypertensive effect.
SIMLO-5 (Amlodipine 5mg &losartan 50mg) reduces blood pressure to a greater degree than either component alone with little incidence of adverse effect.